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You can buy Orlistat (Xenical/Alli) as an over-the-counter alternative to Wegovy in the UK.

However, Orlistat is a very different type of weight-loss medication, and research suggests it’s not as effective as Wegovy in supporting weight loss.

What’s the difference between Orlistat and Wegovy?

Wegovy and Orlistat are weight-loss medications approved for use in the UK. However, they are different medications with distinct dosing schedules, costs, and mechanisms of action on the body.

Orlistat is a lipase inhibitor. Lipases are gut enzymes that break down fat from food, enabling the gut to transport fat into the body to be burnt for energy or stored in our fat cells for later use.

Orlistat blocks lipases, preventing some of the dietary fat from our meals from being digested. This leads to fewer calories being absorbed, which can support weight loss.

Orlistat is a prescription medication produced by two pharmaceutical companies in the UK:

  • GlaxoSmithKline: Alli, 60 mg and available over the counter (no prescription)
  • Roche: Xenical, 120 mg and available with a prescription

Wegovy is a weight-loss jab manufactured by Novo Nordisk. It’s a weekly weight-loss injection with semaglutide as the active ingredient.

Semaglutide is a that helps reduce hunger and appetite, allowing you to eat fewer calories, lose weight, and manage your blood sugar levels.

Wegovy is approved in the UK for individuals living with obesity to help them eat fewer calories and lose weight.

How much do Wegovy and Orlistat cost?

The over-the-counter version of Orlistat will cost around £18 a month, so it’s a very affordable medication.

In comparison, buying Wegovy and the injectable pens required for four weeks from Second Nature will cost £229 a month, rising to £299.

Should I try Orlistat or Wegovy for weight loss?

Orlistat is an affordable medication that is generally well-tolerated. However, it’s less effective than Wegovy. Wegovy is twice as effective as Orlistat for weight loss after one year.

So, if you’re looking for the most affordable weight-loss pill you can purchase over the counter, then Orlistat could be an option.

However, if you have a higher budget and are looking for the most effective weight-loss injection in the UK, semaglutide is a better choice.

Wegovy’s not a magic pill

Semaglutide is designed as an additional tool for weight management and, in most cases, shouldn’t be considered a lifelong medication.

Instead, it should be used to help you kickstart your weight loss and healthy journey while you commit to living a healthier lifestyle.

Ideally, we’d be able to lose weight without medication and lifestyle changes would be enough to support weight loss in the long term.

We’d generally recommend trying Second Nature’s before considering a weight-loss jab.

Changing your habits is the most sustainable way to achieve long-term weight loss, and it’s also less expensive.

At Second Nature, we’ve been trusted by the NHS since 2017 to support people with type 2 diabetes and obesity to lose weight, manage their blood sugar levels, and lead healthier lifestyles for the long term.

In 2022, the NHS in the BMJ that compared the weight loss outcomes of five providers in the National Diabetes Prevention Programme.

Second Nature was more than twice as effective at supporting weight loss than the other four providers.

However, if you’ve decided to try semaglutide (when it’s available) but need support in making positive changes to your lifestyle, Second Nature could be an option for you. But it’s worth noting that we have strict eligibility criteria.

Second Nature has (among the most than any pharmacy on the market).

Frequently asked questions

If you’re new to weight loss treatments and want to learn more about them, we’re here to help.

How do weight loss tablets work?

Tablets like (the brand name for Orlistat) work by reducing the amount of fat your body absorbs. Ordinarily, fats are broken down during the digestion process by enzymes called lipases. Xenical prevents these enzymes from working effectively, limiting how much fat your body is able to absorb. The remaining, undigested fat is then excreted.

How do weight loss injections work?

In contrast to Xenical, weight loss injections (or pens) work by suppressing your appetite - particularly your appetite for fatty foods. Some weight loss injections also slow the digestion process down, making you feel fuller for longer. They’re simple to use - check out our for more information.

How effective are weight loss treatments?

Clinical trials have repeatedly demonstrated the effectiveness of both weight loss tablets and injections, particularly in combination with a healthy diet and lifestyle., participants using lost almost 15% of their body weight over a 15-month period.

How do I place an order?

Starting your weight loss journey is simple with IQ Doctor. To begin, click on a product and then hit the 'Start Consultation' button. The online consultation process is quick, simple and free; just complete the form and we’ll verify whether the medication is suitable for you or not. If it is, you can then place your order and receive it the very next day.

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Most prescription medicines have few side effects. Side effects that can be considered minor orUndigast (orlistat) and.

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Xenical Orlistat (120mg) 84 Capsules

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Explore About Alli & Its Products

Alli is a brand of medication that is used for weight loss. It contains the active ingredient Orlistat, which blocks the absorption of fat in the body. Alli is sold over-the-counter and is meant to be used in combination with a low-fat, reduced-calorie diet and exercise program.

- Alli was launched in 2007 by GlaxoSmithKline.

- It was the first FDA-approved over-the-counter weight loss medication.

- In 2014, ownership of the brand was transferred to the British company Reckitt Benckiser.

- Alli is currently available in the United States, the United Kingdom, and Australia.

Brands Similar to Alli

Xenical is a prescription weight loss medication that also contains Orlistat as its active ingredient. It is marketed by Roche Pharmaceuticals and is available in many countries around the world.

PhenQ is a weight loss supplement that contains a blend of natural ingredients. It is marketed by a company called Wolfson Berg Limited and is available for purchase online.

Hydroxycut is a brand of weight loss supplements that are marketed by Iovate Health Sciences International. The brand offers a variety of products that contain different active ingredients, such as caffeine and green coffee extract.

Top Trending & High Rated Products of Alli

Alli Capsules

Alli Capsules are the brand's flagship product. Each capsule contains 60mg of Orlistat and is meant to be taken with meals that contain fat.

Common Questions Asked by Customers About Alli & Its Products

What is Alli used for?

Alli is used for weight loss. It works by blocking the absorption of fat in the body.

How do I take Alli?

Alli is meant to be taken with meals that contain fat. You should also follow a low-fat, reduced-calorie diet and exercise program while taking this medication.

Is Alli safe?

Alli is generally considered safe when used as directed. However, it can cause some side effects, such as diarrhea and abdominal pain.

How much weight can I expect to lose with Alli?

Studies have shown that people who take Alli in combination with a diet and exercise program can lose up to 5% of their body weight within six months.

Can I take Alli if I am pregnant or breastfeeding?

No, Alli is not recommended for use during pregnancy or breastfeeding.

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What is Xenical?

Xenical is a prescription weight loss aid. This prescription medicine is used to lower the body’s weight (being overweight or obese) and the body will lose most of the fat it is absorbing.

Xenical is a prescription medicine. It is prescribed to help people who are overweight or obese. This medicine is used to treat obesity-related conditions. It is also used to reduce the risk of developing type 2 diabetes and high blood pressure.

Xenical can help reduce the risk of serious side effects of obesity. The most serious side effects are low blood pressure, such as dizziness, fainting, or heart attack. These side effects include:

  • nausea
  • dizziness
  • trouble concentrating
  • bloating

Xenical may also be used in combination with other medicines to reduce the risk of serious side effects of obesity. It is also used to help people who have a history of heart disease, diabetes, high blood pressure, or high cholesterol.

How should I take Xenical?

The dosage and how much you should take depends on your condition. It is usually taken orally with or without food.

Take Xenical exactly as prescribed by your doctor. Follow all directions on your prescription label and read the patient information leaflet provided with your medicine. Your doctor may occasionally change the dose of your medicine.

The dosage and how much you should take depends on your condition and your response to the medicine. If you are taking the pill as a whole, the dose will be the same. Your doctor will let you know the exact amount of medicine you should take.

Xenical is usually taken once or twice a day, depending on your condition. Your doctor will let you know how many times you will need to take Xenical.